iarjmcrIARJMCRIARJMCR2709-3220https://doi.org/10.47310/iarjmcr.2023.v04i02.006A Rare Case Report of Small Cell Carcinoma of VaginaMinhasPathaniaR.JMahajanSmall Cell Carcinoma of Vagina is a rare and a aggressive tumour. It comprises only 1-2% of all gynaecological malignancies .This case report presents a detailed analysis of a 48 year old woman P3L3 with complaint of persistent vaginal discharge for 3 months and a whitish lesion of around 2*2cm size noted in posterior fornix of vagina which bleeds on touch. The patient underwent a series of investigations and a vaginal biopsy which confirmed it to be a small cell carcinoma of vagina. The patient was further evaluated and all the tumour markers namely Synaptophysin, Chromgranin A and Ki67(70-80%)all markers were positive. The patient is Stage 2 Vaginal Cancer and was started on Concurrent EBRT with Etoposide and Cisplatin and currently ongoing CTRT. The case report discusses Diagnostic challenges and Management approaches and timely reporting of such cases as only 44 cases have been reported in entire world of Primary Small Cell Carcinoma of Vagina and still there is ongoing research with the treatment options available.