iarjmcrIARJMCRIARJMCR2709-3220https://doi.org/10.47310/iarjmcr.2022.v03i01.010Case Report: of systemic Amyloidosis at gastrointestinal and Hepatology teaching hospital in Baghdad, IraqAliMohammedFadhilRaghadJawadAL-AkaysheeSallySarmad MohammedAliSystemic amyloidosis is deposition of amyloid in multiple organs with characteristic  histopathologic findings including apple –green birefringence with Congo red staining on polarized light microscopy. We report a case of systemic amyloidosis in 60-year-old man with abdominal distension, weight loss and fatigue. The diagnosis of amyloidosis was done by abdominal fat pad biopsy. At the 3-months follow up, the patient referred to hematologist who advised the patient to do bone marrow biopsy. The patient’s clinical condition had not changed. Conclusion: Further work up and investigations are required to diagnose amyloidosis in patient presented with hepatomegaly, weight loss, nephrotic syndrome, bleeding tendency, peripheral neuropathy and cardiomyopathy.