iarjmcrIARJMCRIARJMCR2709-3220https://doi.org/10.47310/iarjmcr.2022.v03i01.009A Case Report on Motor Neuron Disease (MND)SMShahidulIslamRehanaAkterLimaMotor neuron disease (MNDs) is a neurodegenerative illness with unknown cause, often called amyotrophic lateral sclerosis (ALS). To put it another way, respiratory failure is the most common cause of mortality from progressive muscular weakening and bulbar dysfunction. Until all of the clinical signs and symptoms are present, it may be difficult to confirm the diagnosis [1]. All types of the illness have a considerable differential diagnosis to consider, including curable disorders, thus a professional neurology opinion should always be obtained. Even while only a small percentage of individuals with familial ALS can be shown to have a clear genetic inheritance, research into the biochemical basis of genetic subtypes is yielding crucial results that might one day lead to therapies for sporadic cases of the illness [2]. When there is no cure or disease-modifying treatment, care is supportive and involves a multidisciplinary team. Complex hereditary and environmental variables may play a role in the development of motor neuron disease, and future therapy may include a mix of molecular medicines or stem cell transplants to restore cell integrity. Patients with MND or ALS suffer from a gradual degenerative illness that has no recognized cause. It is helpful to think about the diverse manifestations of motor neuron illnesses in terms of the relative involvement of upper and lower motor neurons when considering the differential diagnosis.