iarjmcrIARJMCRIARJMCR2709-3220https://doi.org/10.47310/iarjmcr.2021.v02i02.012A 42-year Lady with Exanthematous Fever, Meningitis, 8th Nerve Neuritis and Polyradiculopathy with Coagulase Negative Staphylococcus Septicemia: A Case ReportDnyaneshNMorkarInduYadavAim: An approach to atypical presentation of neurobrucellosis and have high index of clinical suscpicion of infective endocarditis in patient presenting with high degree fever. Background: Neurobrucellosis is an endemic zoonotic infection caused by bacterial genus Brucella. Transmission to humans is by infected animals (sheep, cattle, goats, pigs and dogs), urine and by unpasteurized milk. Clinical features usually include headache, fever, joint pain, along with neurologic symptoms such as confusion, meningo-encephalitis, myelitis, peripheral and cranial neuropathies. Case Description: A 48-year-old female presented with two days history of fever, occasional headache, nausea and giddiness and development of decreased hearing in both ears after two days of admission. On detailed work up patient was found to have 8th nerve deafness with polyradiculopathy and proximal myopathy features suggestive of neurobrucellosis. As patient was having high degree fever, differential diagnosis of infective endocarditis was made, as blood culture showed evidence of CoNS , repeated 2D ECHO scans were done with high clinical suspicion, 3RD 2D ECHO showed evidence of vegetations and final diagnosis of infective endocarditis was made. Conclusion: Here we present a case of middle-aged female who presented with neurobrucellosis and simultaneously diagnosed with infective endocarditis. Clinical significance: Brucellosis is a multi-system infectious disease and neurobrucellosis is a rare neurological complication of brucellosis and it may pose a diagnostic challenge in patients with low agglutinin titres and short duration of symptoms. High clinical suspicion with a focus on searching foci of infection is of foremost importance and proper and complete course of IV antibiotics is of prime importance.