iarjmcrIARJMCRIARJMCR2709-3220https://doi.org/10.47310/iarjmcr.2021.v02i01.013CT Imaging Features in Familial Cherubism: Case Report with Review of LiteratureKanikaSekhriSethiSachalSharmaGauravSethiPayalMalhotraBackground: Cherubism is a rare fibro-osseous disease with genetic predisposition, characteristically involving the mandible and maxilla and causing their diffuse enlargement. The course and presentation of the disease is variable, following a benign course with remission of disease in a spontaneous manner with variable degrees of complications and residual disease. The CT imaging features of Cherubism are consistent with multilocular, variable size, irregular radiolucencies involving the maxilla and mandible with sparing of mandibular condyles. Case Report: Brothers, aged 9 and 11 years, presented with painless progressive swelling in bilateral cheeks and mandible. Non contrast CT with 3D reconstruction showed diffuse and extensively involved maxilla and mandible with gross bony expansion and appearance of irregular multiloculated areas of reduced bone density with hallmark imaging feature of sparing of bilateral mandibular condyles. Histopathological evaluation of biopsy of the mandible from left side of both the brothers was done.