iarjmcrIARJMCRIARJMCR2709-3220https://doi.org/10.47310/iarjmcr.2020.v01i01.010O-Arab Hemoglobinosis Fortuitous Discovery about a CaseZTahiriSChellakABoukhiraHemoglobin O-Arab is a rare mutation in Hb, a genetic defect caused by the synthesis of hemoglobin which substitutes for normal hemoglobin A. only the homozygous state is symptomatic, the latter are tolerated but associated with other hemoglobinopathies, it gives a severe clinical form. We report a case of heterozygous O-Arab hemoglobinopathy in a 40 years-old patient of Moroccan origin followed in endocrinology for a test of HbA1c in the context of his type 2 diabetes. HbA1c is performed by HPLC on ADAMS Arkray, showed the presence of a variant detected in the area of ​​HbC. The electrophoretic study of Hb carried out on capillaries (Sebia) at alkaline pH, showed the presence of a variant of Hb in the heterozygous state migrating at the level of the A2 zone, identified as an Hb 0- Arab. In Morocco, Hb O-Arab is an extremely rare mutant of Hb. In the homozygous state, is associated with other hemoglobinopathies, it can present in severe clinical form, hence the importance of the laboratory in the detection of couples at risk in order to offer genetic advice.