srjmcrSRJMCRSRJMCR2788-9548https://doi.org/10.47310/srjmcr.2021.v01i01.002New Trends for Metal Complexes as Potential Therapeutic Agents for Breast Cancer (MCF-7 cell lines)AbdouSaadEl-TablMoshiraMohamed AbdEl-WahedOmnyaEbrahimAbd El-WahabShaimaaFaheemHashimSamehAnwarZawamChemistry Department, Faculty of Science, Menoufia University, EgyptPathology Department, Faculty of Medicine, Menoufia University, EgyptNew Mn(II), Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and Ca(II) complexes of sodium 4,4-(((((1E, 1E)-((4,6-dihydroxy-1,3-phenylene) bis (ethan-1-y1-1-ylidene)) bis (azanylyidene)) bis (ethan-2,1-diyl)) bis (azanediyl)) bis (carbonyl)) diphenolate were prepared and characterized by elemental analyses, IR, UV-Vis spectra, Magnetic moments, Conductivity, 1H-NMR and Mass spectra, Thermal analyses (DTA and TGA) and ESR measurements. The analytical and IR data showed that, the ligand behaves as neutral tetradentate. Molar conductivity in DMF indicate that, the complexes are non-electrolytes. ESR spectra of solid Cu(II) complexes at room temperature show axial type (dx2-y2) with covalent bond character in an octahedral environment. However, Co(II) and Mn(II) complexes showed isotropic type. Ligand and some of its complexes showed inhibitory activity against breast cancer (MCF-7 cell line) compared with standard drug (azathioprine).