srjpSRJPSRJP2788-9564https://doi.org/10.47310/srjp.2021.v01i01.003Syntheses and Pharmacological Evaluation of Novel 9(10H)-Acridone DerivativesAmitGirdharShikhaRahejaNeelamJainSandeepJainAnupamaSetiaAcridone is planer molecule with no atoms deviating by more than 0.02 Å from the molecular plane defined by non-H ring atoms and the oxygen atoms, all torsion angle lies with in +1.5 to -1.5 of 0 to 180 degrees. The molecules adopt a special packing arrangement very similar to that found in anthraquinone & quinaacridone. Hydrogen bonding is maximized in such structures. The synthesis of the acridone derivatives was carried out by condensing 2-chlorobenzoic acid with different substituted anilines to get the substituted acridones. These acridones were further reacted with chloroacetic acid and 2-chloropropionic acid to get their acetic acid and propionic acid derivatives. The structures of the compounds were confirmed by FTIR and 1H-NMR spectral data. The compounds were then evaluated for their analgesic & anti-inflammatory activity against Diclofenac sodium as standard drug. Out of these synthesized derivatives 2-carboxy-9-acridone-N-isopropionic acid showed significant analgesic activity when compared to standard drug Diclofenac sodium. No significant anti-inflammatory activity was found when compared to standard drug.