srjmSRJMSRJM2788-9440https://doi.org/10.47310/srjm.2023.v03i02.015The Role of Ziziphus Spina-Christi Fruit Extract in Modifying Oxidative Stress and Renal Risk Factors Resulting from Exposure to Sodium FluorideMohammedS.AbduameerHaithamL.AbdulhadiSodium fluoride causes increased oxidative stress and increased free radicals, which cause kidney disorders and can cause ischemia. This requires Ziziphus spina-christi extract for its antioxidant properties and to scavenge free radicals. The purpose of this research is to ascertain whether the alcoholic extract of the fruit of the Ziziphus spina-christi tree can reduce oxidative stress and renal disorders resulting from exposure to sodium fluoride (Naf) in male albino rats. 40 albino male rats were divided into 4 groups, each with 10 rats. The first group, Control: was dosed orally with 5 mL/kg distilled water. The second group, Ziziphus: was dosed orally with the alcoholic extract of Sidr fruits 200 mg/kg daily for three months at a dose of 3 ml. The third group, Naf: was injected peritoneally with a sodium fluoride solution 50 mg/kg every other day for 3 months at a dose of 0.1 mL. The fourth group, Ziziphus Naf+: was injected peritoneally with 50 mg/kg of a sodium fluoride solution (every other day) for 3 months, after which it was dosed with 200 mg/kg of the alcoholic extract of Sidr fruits at the same dose for the second and third groups. In a study, male rats were injected with sodium fluoride (Naf) intraperitoneally, resulting in increased kidney function concentrations and MDA levels. However, antioxidant enzymes (GSH, SOD and CAT) were significantly decreased in the third group compared to the first group. In the second group, the antioxidant enzymes were increased, while the third group showed a decrease. The kidneys of the third group showed histological changes, including collapse of the renal glomerulus, atrophy and damage to the cortex. The fourth group showed improvement in kidney function, with normal glomerulus, small expansion in Bowman's space and improvement in convoluted tubules. The combined treatment showed similar improvements to the control group and the second group. The study reveals that the alcoholic extract of Ziziphus fruits exhibits high antioxidant activity, effectively reducing the effects of NaF injections on the kidneys of male albino rats.