srjalsSRJALSSRJALS2788-9386https://doi.org/10.47310/srjals.2023.v03i02.013Genetics study of Leptin Gene Polymorphism for Adolescent obese of Thi-Qar ProvinceTalebK.OdahHudaTaherFaisalDepartment of biology, Collage of Education for Pure Sciences, University of Thi-Qar, 64001, IraqHigh prevalence of obesity that are associated with this phenotype, it is relevant to examine the pathway of leptin in order to determine effective treatment option. The obesity gene, which is one of the main gene that have been linked to the obesity phenotype in human. Mutation of the leptin or leptin receptor gene are associated with obesity and insulin resistance. Therefore, the present study aimed to explain the influence of obesity and the role of leptin gene according to some criteria (gender, age, location and family history). The current study included 500 students secondary school (8-16 years) with highest leptin lacking of obese students (80%) compare with non-obese 48% at the level of significant (p≤0.05). Current study showed also, delete that genes about ten times in obese female student compare with male obese. When samples are divided into old obese and new one, the results Showed That old are subject to gene deletion more Than the new ones.