srjalsSRJALSSRJALS2788-9386https://doi.org/10.47310/srjals.2023.v03i01.012Study of Pseudomonas aeruginosa with antibiotics resistance: a review studyEssmaaHussseinGutefCollege of Dentistry, University of Waist, Waist, IraqThese bacteria was Gram's negative opportunistic pathogen that infects patients with burn, wounds, immunodeficiency, Chronic Obstructive Pulmonary Disorder (COPD), cystic fibrosis, cancer and in severe infections requiring ventilation these bacteria was widely distributed for  nearly all biological regions In addition to continued intense efforts for understand pathogenesis of these bacteria including virulence factors (lipopolysaccharide (LPS), quorum sensing, six types of enzymes secretion, Outer Membrane Vesicles (OMVs), rapid progress has been made in further studying host pathogen interaction, particularly host immune networks involving autophagy, inflammasome, non-coding and nanoparticles. To understand Pseudomonus aeruginosa pathogenesis and host defense against its it will used phage therapy and drugs screen methods. Nothing, much remains to be uncovered about interactions between P. aeruginosa and host immune responses include mechanisms of drug resistance by known or unannotated bacterial virulence factors as well as mammalian cell signaling pathways. The widespread uses of antibiotics and the slow development of effective antimicrobials present daunting challenges and necessitate new theoretical and practical platforms to screen and developed mechanism tested novel drugs to treat acquired infections by this bacteria especially those caused by multidrugs resistance strains, benefited from has advancing in research tools and technology, dissecting this pathogen’s feature has entered into molecular and mechanistic details as well as dynamic and holistic views. however, researchers review  that  the  progressive  and  discuss  current  status  of P. aeruginosa biophysical traits, behaviors, virulence factors, invasive regulators, and host defense patterns against its infections, which point out a new directions for future investigation and add to the design of novel or alternative therapeutics to combat this clinically significant opportunistic bacteria.